Intracoronary Adenovirus-Mediated Delivery and Overexpression of the b2-Adrenergic Receptor in the Heart Prospects for Molecular Ventricular Assistance
نویسندگان
چکیده
Ashish S. Shah, R. Eric Lilly, Alan P. Kypson, Oliver Tai, Jonathan A. Hata, Anne Pippen, Receptor in the Heart : Prospects for Molecular Ventricular Assistance -Adrenergic 2 β Intracoronary Adenovirus-Mediated Delivery and Overexpression of the Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.101.4.408 2000;101:408-414 Circulation. http://circ.ahajournals.org/content/101/4/408 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
BACKGROUND Genetic modulation of ventricular function may offer a novel therapeutic strategy for patients with congestive heart failure. Myocardial overexpression of beta(2)-adrenergic receptors (beta(2)ARs) has been shown to enhance contractility in transgenic mice and reverse signaling abnormalities found in failing cardiomyocytes in culture. In this study, we sought to determine the feasibil...
متن کاملEnhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic strategy for treatment of cardiovascular diseases such as heart failure (HF). Before gene therapy approaches to alter cardiac function can be realized, efficient and reproducible in vivo gene techniques must be established to efficiently transfer transgenes globally to the myocardium. We have been testin...
متن کاملMolecular inotropy: a future approach to the treatment of heart failure?
Maurice et al 1 recently reported that a global ventricular 10-fold overexpression of the b-2 adrenergic receptor, mediated by the intracoronary injection of an adenoviral vector, can be produced in the rabbit. This overexpression resulted in an increased maximum rate of change in left ventricular pressure, dp/dtmax, both at baseline and in response to isoproterenol infusion at 6 days after tra...
متن کاملA Future Approach to the Treatment of Heart Failure?
Maurice et al 1 recently reported that a global ventricular 10-fold overexpression of the b-2 adrenergic receptor, mediated by the intracoronary injection of an adenoviral vector, can be produced in the rabbit. This overexpression resulted in an increased maximum rate of change in left ventricular pressure, dp/dtmax, both at baseline and in response to isoproterenol infusion at 6 days after tra...
متن کاملS100A1 gene therapy preserves in vivo cardiac function after myocardial infarction.
Myocardial infarction (MI) represents an enormous clinical challenge as loss of myocardium due to ischemic injury is associated with compromised left ventricular (LV) function often leading to acute cardiac decompensation or chronic heart failure. S100A1 was recently identified as a positive inotropic regulator of myocardial contractility in vitro and in vivo. Here, we explore the strategy of m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2000